Ovariectomy of rats on Day 3 or Day 4 of pregnancy and autopsy 5 to 6 days later, with no replacement therapy in the intervening period, resulted in an average recovery of five to six blastocysts/rat. When adrenalectomy was coupled with ovariectomy, the blastocyst recovery was markedly reduced. Administration of progesterone to such rats improved the blastocyst yield. When blastocysts from rats subjected to ovariectomy or ovariectomy and adrenalectomy were transferred to pseudopregnant hosts, the proportion which developed into viable foetuses was markedly lower than the proportion developing from blastocysts harvested from intact rats or ovariectomized rats treated with progesterone. Thus, ovariectomy alone or coupled with adrenalectomy appears to exert deleterious effects on both the number and viability of blastocysts in rats.
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