INHIBITION OF OVULATION BY INTRACRANIAL IMPLANTATION OF PROGESTERONE IN THE 4-DAY CYLIC RAT

in Reproduction

Summary.

Crystalline progesterone or cholesterol (50 μg/rat) was implanted stereotaxically into the anterior pituitary gland or median eminence region on the day before pro-oestrus in the 4-day cyclic rat, and the effects of these steroids on ovulation were studied by examining tubal ova at autopsy on the expected day of oestrus. Progesterone (at 1/10 the effective subcutaneous dose) implanted at either location proved significantly more active in interfering with ovulation than cholesterol (P<0·01). The data provide evidence that progesterone acts at both the hypothalamic and pituitary levels to interfere with ovulation.

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    Society for Reproduction and Fertility

 

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