LACK OF OESTROGENIC EFFECT OF o,p′-DDT ON THE IMPLANTATION OF RAT BLASTOCYSTS

in Reproduction

According to a number of reports, the administration of o,p′-DDT produces effects which mimic those of oestrogens in causing increases in chicken, Gallus domesticus, and quail, Coturnix coturnix japonica, oviduct weight and the uterine weight of immature and ovariectomized rats (Bitman, Cecil, Harris & Fries, 1968; Levin, Welch & Conney, 1968; Duby, Travis & Terrill, 1971). The glycogen content of these organs is also increased as the result of o,p′-DDT injections (Bitman et al., 1968), while the age of vaginal opening in rats is decreased (Wrenn, Wood, Fries & Bitman, 1970). These results might be explained on the basis of an interference of o,p′-DDT with endogenous oestrogen metabolism (Kupfer, 1967, 1969). However, in ovariectomized rats, o,p′-DDT increased the uterine weight and

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     An official journal of

    Society for Reproduction and Fertility

 

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