The mechanism controlling the last step in ovulation—ejection of the follicular contents—is not yet fully explained. Several hypotheses have been proposed, for example, increased intrafollicular pressure (Bartelmez, 1912; Smith, 1934; Jensen & Zacharia, 1960), contractions of the follicular wall (Lipner & Maxwell, 1960), and enzymatic breakdown (digestion) of the follicular wall (Espey & Lipner, 1965; Espey, 1967; Espey, Slagter, Weymouth & Rondell, 1965; Espey & Rondell, 1968; Rondell, 1970) but none has been proven to be the mechanism of ovulation. However, it is agreed by all that a fully developed stigma is essential for ovulation. Recently, spontaneous contractions of cat ovaries in vitro were demonstrated and a response to adrenergic drugs was shown (Rocereto, Jacobowitz & Wallach, 1969). These contractions were assumed to be under the control of sympathetic impulses mediated through the adrenergic innervation (Jacobowitz & Wallach, 1967; Rocereto et al., 1969) to the smooth muscle cells found in
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