HISTOCHEMICAL LOCALIZATION OF 3βHYDROXYSTEROID DEHYDROGENASE IN THE RAT EPIDIDYMIS

K. A. MONIEM

doi:10.1530/jrf.0.0280461

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HISTOCHEMICAL LOCALIZATION OF 3βHYDROXYSTEROID DEHYDROGENASE IN THE RAT EPIDIDYMIS

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K. A. MONIEM

K. A. MONIEM
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DOI:: https://doi.org/10.1530/jrf.0.0280461

Volume/Issue:: Volume 28: Issue 3

Page Range:: 461–NP

Article Type:: Research Article

Online Publication Date:: Mar 1972

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Recent studies have demonstrated that cholesterol and testosterone may be synthesized in vitro from acetate by mouse and rat epididymides (Hamilton, Jones & Fawcett, 1969; Hamilton & Fawcett, 1970). McGadey, Baillie & Ferguson (1966) were the first to demonstrate histochemically some of the steroid-metabolizing enzymes in the hamster epididymis, and subsequently a number of workers (Gloyna & Wilson, 1969; Inano, Machino & Tamaoki, 1969) have verified by biochemical means the existence of steroid-converting enzymes in the epididymal tissue of a number of mammals. McGadey et al. (1966), however, did not find 3β-hydroxysteroid dehydrogenase in the hamster epididymis. This enzyme is very much concerned with steroid biosynthesis, converting pregnenolone and dehydroepiandrosterone (DHA) to progesterone and androstenedione, respectively (Baillie, Ferguson & Hart, 1966). In many vertebrates, steroid-producing organs

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