The lh content of the pituitary of rabbits in various reproductive states was assayed by the ovarian ascorbic acid depletion method. It was highest in unmated rabbits and decreased significantly (P<0·01) during both pseudopregnancy and pregnancy. Administration of progesterone (20 mg/day for 10 days) reduced pituitary lh in unmated rabbits to levels similar to those found during pseudopregnancy and pregnancy. It is inferred that the capacity of the pituitary gland to accumulate lh during pseudopregnancy and pregnancy decreases mainly as a result of secretion of progesterone.
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