DISTRIBUTION OF [14C]α-CHLOROHYDRIN IN MICE AND RATS

in Reproduction

Alpha-chlorohydrin (3-chlor-1,2 propanediol) possesses antifertility properties when administered to male rats, hamsters, guinea-pigs, rams and monkeys (Ericsson, 1968; Ericsson & Norland, 1970). The compound is thought to exert its action on the epididymis, since high doses of α-chlorohydrin cause vascular disturbances in the proximal part of the epididymis (Gunn, Gould & Anderson, 1969; Samojlik & Chang, 1970; Kreider & Dutt, 1971). There is also a time delay between administration of the drug and the onset of inhibition of fertility (Ericsson, 1968; Turner, 1971). Impaired sperm motility which has been observed (Coppola, 1969; Samojlik & Chang, 1970), has been thought to be due to oxygen deficiency in the epididymis following vascular trauma. Coppola (1969) and Gunn et al. (1969) suggested that α-chlorohydrin might act as a metabolic antagonist to

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     An official journal of

    Society for Reproduction and Fertility

 

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