EFFECTS OF PROGESTERONE ON THE FATE OF BLASTOCYSTS IN RATS HYPOPHYSECTOMIZED ON THE FIRST DAY OF PREGNANCY

in Reproduction

Summary.

The beneficial effect of progesterone on blastocyst survival in the uterus was shown in rats hypophysectomized on Day 1 of pregnancy. Treatment with progesterone (2 mg/day) on Day 1, Day 1 and Day 6, or Days 1 to 5 could maintain most blastocysts for only 5 days following the last injection; during the next 5 days, many disintegrated in the uterus. Daily injections of 2 mg progesterone, however, could maintain most blastocysts for as long as Day 53.

In hypophysectomized rats, the developmental potential of blastocysts deteriorated rapidly even though the rats received 2 mg progesterone daily. By Day 20, only 23% of blastocysts were capable of developing into full-term fetuses compared with 52% in rats ovariectomized on Day 4 and injected daily with 2 mg progesterone. By Day 52, none of the blastocysts from either group of animals developed to term although many still retained the ability to implant.

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