EFFECT ON THE OFFSPRING OF REPEATED CAFFEINE ADMINISTRATION TO PREGNANT RATS

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Authors:
ENID F. GILBERT
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W. R. PISTEY
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DOI:
https://doi.org/10.1530/jrf.0.0340495
Volume/Issue:
Volume 34: Issue 3
Page Range:
495–499
Article Type:
Research Article
Online Publication Date:
Sep 1973
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Summary.

Repeated intraperitoneal injections of caffeine given to rats in dosages ranging from 4 to 16 mg daily throughout pregnancy resulted in significant resorptions and decrease in the birth weight of the offspring. These effects were dose-related. Developmental malformations, however, were not observed in the offspring at these dosage levels.

These results indicate that caffeine, even in low doses which at the lower levels of the experiment may approximate to the daily human intake of a heavy coffee consumer, suppresses growth of embryonic and fetal tissues.

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Sept 2018 onwards Past Year Past 30 Days
Full Text Views 447 288 16
PDF Downloads 166 48 4

 

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Print ISSN:
1470-1626
Online ISSN:
1741-7899