The antifertility effects and histopathological changes in the reproductive tract of male rats following administration of α-chlorohydrin, α-bromohydrin, epi-chlorohydrin and glycidol were compared. Contrary to earlier reports, α-bromohydrin induced bilateral spermatocoeles and permanent sterility in rats but did not produce the functional epididymal sterilizing effect of α-chlorohydrin. Glycidol reproduced the primary sterilizing effect of α-chlorohydrin but not the lesions in the proximal caput epididymidis. Epi-chlorohydrin showed activities resembling those of α-chlorohydrin. The primary lesion in the proximal caput epididymidis was seen specifically to involve the `conus' and adjacent regions with sloughing of the epithelium. This may impair the secretory/absorptive function of this region with ensuing severe damage to the thin-walled ductuli efferentes. Except where granulomata were formed, restoration of the epithelium occurred. The apical region of the proximal caput remained undamaged throughout.
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