ANTITESTICULAR AND ANTIFERTILITY ACTIVITY OF A PIPECOLINOMETHYLHYDROXYINDANE IN RATS
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Summary.
Treatment with dl-6-(N-α-pipecolinomethyl)-5-hydroxyindane maleate (PMHI) has been found to depress testicular weight and interfere with spermatogenesis and fertility in the male rat. At equal doses by weight, PMHI caused a greater reduction in testicular weight than WIN 18446, nitrofurazone, methallibure and diethylstilboestrol, but lesser reductions in seminal vesicle and ventral prostate weights than were obtained with the two antigonadotrophic compounds, methallibure and diethylstilboestrol. Doses of the compound which were effective in the male rat did not interfere with normal oestrous cycles or fertility when administered to female rats.
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Print ISSN: 1470-1626
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