FURTHER STUDIES ON THE ANTITESTICULAR ACTIVITY OF A PIPECOLINOMETHYLHYDROXYINDANE
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Summary.
Treatment with dl-6-(N-α-pipecolinomethyl)-5-hydroxyindane maleate (PMHI) depressed testis weights in immature rats, mice, hamsters and guinea-pigs. Similar effects on testicular weight were observed in adult rabbits, dogs and two species of monkey. Concurrent administration of testosterone, gonadotrophins, dl-tocopherol acetate, and methionine did not prevent the testicular weight reduction induced with PMHI in the immature rat. In hypophysectomized rats, the administration of PMHI caused further significant reduction in testicular weights. These data indicate that the activity of PMHI is directly on the testis and is not mediated by way of the hypothalamus-pituitary-gonadal axis.
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