THE HALF-LIFE OF HUMAN PLACENTAL LACTOGEN IN NON-IMMUNE AND IMMUNE RHESUS MONKEYS
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Summary.
A dose of human placental lactogen (HPL), calculated to produce an initial plasma concentration ten times the maximal levels found in pregnant women, was injected intravenously into adult non-pregnant female rhesus monkeys (Macaca mulatta). The disappearance curves in non-immune animals can be best explained by a double exponential function: the half-life of HPL in these animals was approximately 10 min in the first phase and approximately 50 min in the second phase.
Circulating HPL could not be demonstrated in the serum of monkeys immunized previously with HPL.
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