IMPLANTATION IN RATS TREATED NEONATALLY WITH TESTOSTERONE PROPIONATE
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Although a previous study (Kramen, 1969) demonstrated normal uterine decidual sensitivity in young female rats which had been given low (50 μg) doses of testosterone propionate (TP) shortly after birth, it is not known if uterine sensitivity to blastocyst implantation is normal in such rats. The present study was undertaken to determine if the uteri of adult rats treated neonatally with TP could support implantation.
Female Holtzman rats were treated on Day 5 of life with 50 μg TP as previously described (Kramen & Johnson, 1971). Various hormonal treatments were used to induce implantation in 100- to 120-day-old TP-treated rats which were mated after ovulation had been induced. In one group, the progesterone necessary to maintain pregnancy was supplied by supporting corpora ultea with a normal female pituitary implanted beneath the kidney capsule (Nikitovich-Winer
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