Autografts and allografts of skin were transplanted into the uteri of ewes to determine the influence of ovariectomy and hormone replacement on survival of the grafts. The fate of the grafts in sheep differed from that previously reported for the rat. Autografts were accepted in the uteri of ovariectomized ewes. Intrauterine allografts were rejected, however, when oestrogen and progesterone were given to the hosts in doses sufficient to maintain pregnancy.
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