INDUCTION OF OVULATION BY PREGN-5-ENE-3,20-DIONE AND PROGESTERONE IN IMMATURE RATS TREATED WITH PMSG AND PHENOBARBITAL
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Summary.
Progesterone and pregn-5-ene-3,20-dione, the proposed intermediate between pregnenolone and progesterone in the rat ovary, were able to overcome the phenobarbital (PB)-induced block of ovulation in the PMSG-primed immature rats when given 3½ hr after PB.
Pregnenolone failed to cause ovulation in any of the animals treated with phenobarbital, providing support for the hypothesis that the ovulation-inhibiting action of PB may be due in part to its inhibitory action on the step in steroidogenesis between pregnenolone and progesterone.
The principal metabolites of progesterone in the hypothalamus and uterus, 5α-pregnane-3,20-dione and 3α-hydroxy-5α-pregnan-20-one, were not able to overcome the PB-induced block of ovulation. These results suggest that the action of progesterone in overcoming the PB-induced block of ovulation is not because of its transformation to these two compounds.
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