THE ONSET AND DURATION OF INFERTILITY IN HAMSTERS TREATED WITH α-CHLOROHYDRIN
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Summary.
Fertile male hamsters were injected daily with 66 mg α-chlorohydrin/kg to determine the onset and duration of infertility. None of the males became infertile within the first 2 days but marked loss of fertilizing ability of spermatozoa had occurred by 24 hr from the second injection. Infertility occurred in all five males after the fourth dose. The fertilizing ability of the spermatozoa was not impaired when the equivalent of four daily doses was given as a single dose, thus indicating that sequential daily treatment was necessary for the induction of infertility. The prompt recovery of fertilizing ability of spermatozoa in males which had ligated ductuli efferentes and were given four daily doses of α-chlorohydrin (66 mg/kg) shows that transport of epididymal spermatozoa and their acquisition of fertilizing ability are not influenced by the drug.
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