FETAL RESORPTION INDUCED BY DISULFIRAM IN RATS

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Authors:
M. P. SALGO
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G. OSTER
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DOI:
https://doi.org/10.1530/jrf.0.0390375
Volume/Issue:
Volume 39: Issue 2
Page Range:
375–377
Article Type:
Research Article
Online Publication Date:
Aug 1974
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Summary.

When pregnant rats given disulfiram, a copper-chelating agent, orally at a dose of 100 mg per day from Day 3 of pregnancy were killed on Day 12 or 13, 83% of the conceptuses showed fetal resorption. In any rat, fetal resorption was uniform among all the conceptuses. The similarity of our results with those found by others for rats fed on a copper-deficient diet suggests that disulfiram renders copper unavailable for the developing embryo.

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Print ISSN:
1470-1626
Online ISSN:
1741-7899