THE EFFECT OF OESTROGEN AND PROGESTERONE ON CO2 PRODUCTION BY `DELAYED IMPLANTING' MOUSE EMBRYOS

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Authors:
C. A. TORBIT
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and
H. M. WEITLAUF
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DOI:
https://doi.org/10.1530/jrf.0.0390379
Volume/Issue:
Volume 39: Issue 2
Page Range:
379–382
Article Type:
Research Article
Online Publication Date:
Aug 1974
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Menke & McLaren (1970) reported that CO2 production by `delayed implanting' mouse embryos is significantly lower than that of blastocysts implanting at the normal time. They suggested that the metabolic quiescence associated with delayed implantation could result either from an inhibitory effect of progesterone, or from a lack of stimulation by oestrogen. The present experiments were undertaken to distinguish between these possibilities; maternal levels of oestradiol and progesterone were manipulated and the effect on CO2 production by preimplantation embryos was determined.

Sexually mature, virgin, white Swiss mice at random stages of the oestrous cycle were induced to ovulate with injections of gonadotrophins (Fowler & Edwards, 1957). The females were placed with fertile males and mating was confirmed by the presence of a vaginal plug on the next

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Print ISSN:
1470-1626
Online ISSN:
1741-7899