EFFECT OF IUD ON UTERINE CYCLIC AMP AND THE ACTIVITIES OF ADENYL CYCLASE AND PHOSPHODIESTERASE DURING THE OESTROUS CYCLE AND EARLY PREGNANCY IN RATS

M. K. SIM

doi:10.1530/jrf.0.0390399

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EFFECT OF IUD ON UTERINE CYCLIC AMP AND THE ACTIVITIES OF ADENYL CYCLASE AND PHOSPHODIESTERASE DURING THE OESTROUS CYCLE AND EARLY PREGNANCY IN RATS

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M. K. SIM

M. K. SIM
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DOI:: https://doi.org/10.1530/jrf.0.0390399

Volume/Issue:: Volume 39: Issue 2

Page Range:: 399–402

Article Type:: Research Article

Online Publication Date:: Aug 1974

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Oestrogen administration to spayed rats produces biochemical changes in the uterus. Wrenn, Wood & Bitman (1969a) found that oestrogen increased the glycogen and nucleic acid content and the weight of the uterus and Szego & Davis (1967) noted that oestrogen raised the level of cyclic AMP in the uterus. The presence of an IUD has been shown to cause similar changes (Wrenn et al., 1969b). There thus appears to be a similarity between the action of oestrogen and the effect of an IUD. The effect of an IUD on uterine cyclic AMP was investigated in rats during the oestrous cycle and early pregnancy. The activities of adenyl cyclase and phosphodiesterase were also studied.

Batches of about ten female Sprague-Dawley rats about 10 weeks old and weighing from 170 to 200 g were used. The stage

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