RESPONSE OF MOUSE OVARIES IN VIVO AND IN ORGAN CULTURE TO PREGNANT MARE'S SERUM GONADOTROPHIN AND HUMAN CHORIONIC GONADOTROPHIN

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Authors:
P. NEAL
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T. G. BAKER
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DOI:
https://doi.org/10.1530/jrf.0.0390411
Volume/Issue:
Volume 39: Issue 2
Page Range:
411–414
Article Type:
Research Article
Online Publication Date:
Aug 1974
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The response of the ovary to exogenous gonadotrophins is known to be dependent upon the age of the animal at the time of treatment (Zarrow & Wilson, 1961; McLaren, 1967). The present experiments were carried out to reinvestigate this phenomenon in intact mice and to determine whether this relationship also holds when mouse ovaries are treated with PMSG and HCG in organ culture.

For the in-vitro studies, mice of the Schofield albino strain aged 14, 21, 28, 35 or 49 days post partum (p.p.) were killed by dislocation of the neck and their ovaries were cleanly dissected free from adnexa. The technique for organ culture has been described in full in our earlier papers (Baker & Neal, 1969, 1972). At the onset of culture, PMSG ('Gestyl': Organon Laboratories, London)

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Print ISSN:
1470-1626
Online ISSN:
1741-7899