Groups of rats were assigned respectively to one of six unilateral surgical treatments: scrotal sham operation, scrotal vasectomy without ligation, scrotal vasectomy with ligation, abdominal sham operation, abdominal vasectomy without ligation, and abdominal vasectomy with ligation. Three months later, the mean testis weight was unaffected by the various operative procedures, but the variance of testis weight was greater following vasectomy with ligation of the ductus deferens and after operations involving the abdominal approach. Mean testicular sperm concentrations were similar in all groups, but variance of this parameter was increased after abdominal operations. While vasectomy appears to be relatively harmless, certain procedures, such as abdominal vasectomy with ligation, disturb the rat testis more than others.
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