Premature oviposition was induced in the coturnix quail by intrauterine injection of prostaglandins, essential fatty acids, dibutyryl cyclic AMP, and human seminal plasma. Aspirin and indomethacin inhibited the response to prostaglandin precursors but not to PGE1. Theophylline potentiated the effect of dibutyryl cyclic AMP and low doses of PGE1 and PGE2. Fowl, turkey, bull, boar, and stallion seminal plasma was ineffective on oviposition and contained only small amounts of prostaglandins as determined by radioimmunoassay. It is suggested that prostaglandins may have a physiological rôle in the regulation of oviposition.
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