EFFECT OF AMINOGLUTETHIMIDE ON REPRODUCTIVE PROCESSES IN FEMALE RATS

in Reproduction
Authors:
W. J. EVERSOLE
Search for other papers by W. J. EVERSOLE in
Current site
Google Scholar
PubMed Close
and
D. J. THOMPSON
Search for other papers by D. J. THOMPSON in
Current site
Google Scholar
PubMed Close
DOI:
https://doi.org/10.1530/jrf.0.0400125
Volume/Issue:
Volume 40: Issue 1
Page Range:
125–132
Article Type:
Research Article
Online Publication Date:
Sep 1974
Free access

Sign up for journal news

Summary.

Adult female rats injected subcutaneously with 100 mg aminoglutethimide phosphate (AGP)/kg/day for 4 weeks failed to become pregnant when placed in cohabitation with males during the last 2 weeks of the injection period. Lower doses depressed the fertility rate and reduced the litter size: the average litter size of three of eleven rats given 50 mg/kg/day was 4·7 young and of four of eleven rats given 25 mg was 7·0 young. Twenty-nine controls averaged 10·1/litter. Doses of 100 mg AGP/kg/day stopped vaginal cycling, prevented ovulation in adults, and delayed dissolution of the vaginal membrane in pubertal rats. Histological studies of the ovaries from rats with initial ages of 17 or 21 days which were injected with 25 to 100 mg AGP/kg/day for 2 weeks showed an increase in the number and size of vesicular follicles. Treatment of 27-day-old rats with 25 mg/kg/day for 2 weeks reduced the number of CL and three of four rats given 50 mg had ovaries lacking such bodies; all control ovaries in this group contained CL. These findings are taken as evidence that AGP inhibits ovulation but does not prevent follicular maturation.

Reproduction is committed to supporting researchers in demonstrating the impact of their articles published in the journal.

The two types of article metrics we measure are (i) more traditional full-text views and pdf downloads, and (ii) Altmetric data, which shows the wider impact of articles in a range of non-traditional sources, such as social media.

More information is on the Reasons to publish page.

Sept 2018 onwards Past Year Past 30 Days
Full Text Views 114 35 1
PDF Downloads 39 9 1

 

  • Collapse
  • Expand
Print ISSN:
1470-1626
Online ISSN:
1741-7899