SYNTHETIC LH-RELEASING FACTOR AND CLOMIPHENE STIMULATION IN OLIGOSPERMIC MALES WITH NORMAL FSH EXCRETION

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Authors:
J. MAUSS
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G. MOHNFELD
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, and
G. BÖRSCH
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DOI:
https://doi.org/10.1530/jrf.0.0400171
Volume/Issue:
Volume 40: Issue 1
Page Range:
171–175
Article Type:
Research Article
Online Publication Date:
Sep 1974
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It now seems reasonably established that males with a severe impairment of testicular tubular function tend to have elevated FSH levels, while, contrary to previous concepts, gonadotrophin levels associated with the syndrome of hypogonadotrophic hypogonadism are not necessarily low but are frequently in the lower normal adult range (Franchimont, Burger & Legros, 1973). This emphasizes the need for reliable diagnostic methods to differentiate patients with hypogonadotrophic hypogonadism from other sub- or infertile males. Tests of hypothalamic and pituitary function, utilizing clomiphene citrate and LH-releasing factor (LH-RF) respectively, have been successfully used (Santen, Leonard, Sheris, Gandy & Paulsen, 1971; Marshall, Harsoulis, Anderson, McNeilly, Besser & Hall, 1972). The performance of these stimulation tests involves the assay of FSH and LH, usually in serum or plasma, and their application has therefore been restricted to a few well-equipped endocrinological

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Print ISSN:
1470-1626
Online ISSN:
1741-7899