THE EFFECT OF OESTROGEN AND PROGESTERONE ON THE RELEASE OF PROSTAGLANDINS FROM THE UTERUS OF THE OVARIECTOMIZED GUINEA-PIG

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Authors:
F. R. BLATCHLEY
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and
N. L. POYSER
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DOI:
https://doi.org/10.1530/jrf.0.0400205
Volume/Issue:
Volume 40: Issue 1
Page Range:
205–209
Article Type:
Research Article
Online Publication Date:
Sep 1974
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Evidence is accumulating (Blatchley & Donovan, 1973) that the uterine luteolytic hormone in mammals is prostaglandin F2α (PGF2α). This prostaglandin is released from the guinea-pig uterus under conditions associated with premature luteolysis, such as bead insertion (Poyser, Horton, Thompson & Los, 1971) and oestrogen treatment (Blatchley, Donovan, Poyser, Horton, Thompson & Los, 1971), and both the synthesis and release of PGF2α increase toward the end of the oestrous cycle when natural luteal regression occurs (Poyser, 1972; Blatchley, Donovan, Horton & Poyser, 1972). The factors involved in the regulation of the cyclic release of prostaglandin from the uterus have not been extensively studied, although Pickles (1967) suggested that progesterone may regulate the synthesis of prostaglandins in the human uterus as the concentration

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Print ISSN:
1470-1626
Online ISSN:
1741-7899