THE EFFECT IN VITRO OF PROSTAGLANDINS WITH OXYTOCIN ON THE MILK-EJECTION ACTIVITY OF LACTATING SOW MAMMARY TISSUE
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A study by Turker & Kiran (1969) revealed that single retrograde intraarterial (i.a.) injections of prostaglandin E1 (PGE1) did not produce a change in milk-ejection pressure in the lactating rabbit, but could inhibit the milk-ejection response to oxytocin. The minimal dose range of PGE1 required to produce an inhibition of milk-ejection pressure by oxytocin was 0·1 to 1 μg PGE1 i.a.
Halder, Maiweg & Grosvenor (1970) showed that PGE1 could abolish the milk-ejection activity of oxytocin in the rat.
A study by McNeilly & Fox (1971) indicated that PGE1, PGE2, PGF1α and PGF2α, all possessed inherent milk-ejection activity in the guinea-pig. They found that in no case did the i.a. injection of any of these four prostaglandins in amounts up to 30 μg cause any decrease
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