Growth hormone (HGH) responses to insulin-induced hypoglycaemia were examined in sixteen normal women and twenty-eight women with secondary amenorrhoea. A normal response (blood levels rising above 10 ng/ml) was found in fifteen of sixteen (94%) of the controls but in only nineteen of twenty-eight (68%) of the patients with amenorrhoea. Oestrogen administration induced a normal response in only two out of six patients with a previously abnormal result. The patients with subnormal HGH responses all had a low gonadotrophin excretion, but tests of thyroid and adrenocortical function were normal and pituitary fossa X-rays were normal. This tendency to a poor HGH response must be taken into account when screening amenorrhoeic patients for pituitary tumours.
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