EFFECTS OF METYRAPONE ON REPRODUCTIVE ORGANS OF THE MEADOW VOLE, MICROTUS PENNSYLVANICUS

in Reproduction

Summary.

Reproductive organ weights and histology were examined in male and female voles, Microtus pennsylvanicus, which had received daily injections of metyrapone (100 mg/kg) or saline for 21 days from 30 days of age. In females receiving metyrapone, body weight and weights of ovaries and uteri were significantly decreased. In metyrapone-treated males, seminal vesicles were 70% lighter than in saline-injected controls. Histological examination of the reproductive organs confirmed inhibition of reproductive development and maturation in metyrapone-treated voles. The results with metyrapone lend further support to the hypothesis that increased pituitary-adrenal activity may impair reproductive function in rodents.

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     An official journal of

    Society for Reproduction and Fertility

 

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