THE EFFECT OF MESTRANOL AND LYNOESTRENOL ON OVARIAN HISTAMINE IN THE RAT

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Summary.

The effect of oral treatment of rats for 12 days with the contraceptive steroids, mestranol (0·08 mg/rat/day) and lynoestrenol (2·5 mg/rat/day) alone and in combination, on ovarian histamine content was studied. All treatments resulted in a decrease in the histamine content per ovary, but this was only significant for mestranol alone. When the results were expressed in terms of histamine per g ovary, treatment with mestranol resulted in a significant decrease while lynoestrenol and mestranol plus lynoestrenol treatment resulted in a non-significant increase.

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