THE STIMULATION OF MOUSE OVARIAN FOLLICULAR GROWTH IN VITRO BY DIBUTYRYL CYCLIC ADENOSINE 3':5' MONOPHOSPHATE

in Reproduction

Both FSH and LH stimulate ovarian follicular growth during prolonged incubation in vitro, the response to FSH being detectable after 1 day whereas that to LH first appears after 3 days (Ryle, 1971a, b). Both hormones also enhance the synthesis of cyclic adenosine 3':5' monophosphate (cyclic AMP) by ovarian tissue during brief periods of incubation (Fontaine, Fontaine-Bertrand, Delerue-Labelle & Salmon, 1971; Koch, Zor, Pomerantz, Chobsiang & Lindner, 1973; Mason, Schaffer & Toomey, 1973). Most studies on the effects of cyclic AMP on endocrine target tissues have involved only short exposures and rapid responses. Both rabbit and rat Graafian follicles, however, undergo luteinization following treatment with either LH or cyclic AMP (Miller & Keyes, 1972; Ellsworth & Armstrong, 1973) and adrenal cortical cells of the fetal rat exposed to cyclic AMP for several days eventually undergo changes similar to those induced by ACTH (Milner, 1972). It was therefore of interest

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