EFFECT OF Δ9-TETRAHYDROCANNABINOL ON THE MEMBRANE PERMEABILITY OF BULL SPERMATOZOA TO POTASSIUM

in Reproduction
Authors:
E. GIBERMANN
Search for other papers by E. GIBERMANN in
Current site
Google Scholar
PubMed Close
,
S. GOTHILF
Search for other papers by S. GOTHILF in
Current site
Google Scholar
PubMed Close
,
A. SHAHAR
Search for other papers by A. SHAHAR in
Current site
Google Scholar
PubMed Close
, and
T. BINO
Search for other papers by T. BINO in
Current site
Google Scholar
PubMed Close
DOI:
https://doi.org/10.1530/jrf.0.0420389
Volume/Issue:
Volume 42: Issue 2
Page Range:
389–390
Article Type:
Research Article
Online Publication Date:
Feb 1975
Free access

Sign up for journal news

Israel Institute for Biological Research, Ness-Ziona, Israel

(Received 1st August 1974)

Previous investigations in our laboratory have indicated that Δ9-tetrahydrocannabinol (THC), the main psychoactive component of cannabis (hashish), adversely affected bull spermatozoa in vitro. The effect consisted of a decrease in respiration and ATP content, changes in motility, and morphological abnormalities, such as swelling of the mitochondrial helix region (Shahar & Bino, 1973; Shahar, Bino, Kalay & Homonnai, 1973). At the same time, THC has been found to decrease ATPase in rat and human erythrocytes, protecting these cells against hypotonic haemolysis and inhibiting cation uptake (Chari-Bitron, 1971; Raz, Schurr & Livne, 1972; Gibermann, Chari-Bitron, Millo & Gothilf, 1974). We therefore decided to investigate the possible changes in the membrane permeability of bull sperm cells to potassium following exposure to THC.

Freshly collected bull spermatozoa (Artificial Insemination Service, Beit Dagan, Israel) were washed and suspended in modified Ringer, pH 7·3, to

Reproduction is committed to supporting researchers in demonstrating the impact of their articles published in the journal.

The two types of article metrics we measure are (i) more traditional full-text views and pdf downloads, and (ii) Altmetric data, which shows the wider impact of articles in a range of non-traditional sources, such as social media.

More information is on the Reasons to publish page.

Sept 2018 onwards Past Year Past 30 Days
Full Text Views 110 27 0
PDF Downloads 62 19 3

 

  • Collapse
  • Expand
Print ISSN:
1470-1626
Online ISSN:
1741-7899