EFFECT OF A COPPER IUD ON THE INCORPORATION OF [3H]THYMIDINE AND [5-3H]URIDINE INTO THE ENDOMETRIUM OF THE RABBIT DURING EARLY PREGNANCY

HANS GRUNDSELL

doi:10.1530/jrf.0.0420447

Jump to Content

EFFECT OF A COPPER IUD ON THE INCORPORATION OF [³H]THYMIDINE AND [5-³H]URIDINE INTO THE ENDOMETRIUM OF THE RABBIT DURING EARLY PREGNANCY

in Reproduction

Author:

HANS GRUNDSELL

HANS GRUNDSELL
Search for other papers by HANS GRUNDSELL in
Current site
Google Scholar
PubMed

View More View Less

DOI:: https://doi.org/10.1530/jrf.0.0420447

Volume/Issue:: Volume 42: Issue 3

Page Range:: 447–458

Article Type:: Research Article

Online Publication Date:: Mar 1975

Free access

Download PDF

Summary.

The influence of a copper IUD on the incorporation of [³H]thymidine and [5-³H]uridine into the endometrium of the rabbit was studied during early pregnancy. The effect of the copper device was compared with those of polyethylene and platinum IUDs.

The comparison showed that the presence of a copper IUD resulted in a significantly lower incorporation of [³H]thymidine on the 3rd day of pregnancy and in a higher incorporation of [³H]thymidine and [5-³H]uridine on the 5th day of pregnancy. The increase in the total amount of DNA in the endometrium in early pregnancy was markedly reduced in the copper IUD-containing horn, and auto-radiography showed that the labelling frequency of epithelial cells in the endometrium was significantly reduced. A possible effect of the copper IUD on the stromal cells is discussed.

These effects of copper could be due either to an altered hormonal responsiveness of the endometrium in the presence of copper or to a `direct' effect of copper on nucleic acid metabolism.

Reproduction is committed to supporting researchers in demonstrating the impact of their articles published in the journal.

The two types of article metrics we measure are (i) more traditional full-text views and pdf downloads, and (ii) Altmetric data, which shows the wider impact of articles in a range of non-traditional sources, such as social media.

More information is on the Reasons to publish page.