ANTIFERTILITY EFFECTS OF SUBSTITUTED ACETAMIDOBENZENE DERIVATIVES IN FEMALE ALBINO RATS

in Reproduction

Department of Chemical Engineering and Technology, Panjab University, Chandigarh-160014, and *Department of Pharmacology, Postgraduate Institute of Medical Education and Research, Chandigarh, India

(Received 10th June 1974)

The use of nitrogen mustards as chemotherapeutic agents in the treatment of certain neoplastic diseases has been well established by a large number of workers (Montgomery, 1959; Creech, Breuninger, Hankwitz, Polsky & Wilson, 1960; Ross, 1962). A large number of different compounds have been screened in various test systems in vitro and in vivo for anticancerous, antibacterial, antimicrobial and antifertility action and some useful results have been reported (see Mori, Clarkson, O'Connor Lawrence, 1962; Schmidt, Fradkin, Sullivan, & Flower, 1965; Burger, 1970). A series of substituted acetamidobenzene derivatives was screened for antifertility effects by the method of Khanna & Chaudhry (1968) to detect any antizygotic, blastocytotoxic, anti-implantation and abortifacient activity. The derivatives contained a mono- or bis-, 2-haloethyl moiety linked through a methylene group

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