UTERINE DECIDUALIZATION IN RATS GIVEN TESTOSTERONE PROPIONATE NEONATALLY
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Departments of Obstetrics and Gynecology and Physiology, University of Kansas Medical School, Kansas City, Kansas, U.S.A.
(Received 26th June 1974)
There has been little success in inducing a decidual reaction in the uteri of adult female rats given androgen neonatally. Burin, Thevenot-Duluc & Mayer (1963) reported a positive reaction after scratching the antimesometrial lining and giving progesterone (5 mg) daily for 8 days, but the incidence of success, the age of the animals, and the criteria for decidualization were not given. Barraclough (1967) reported that 25% of adult females given HCG to induce ovulation, and reserpine to sustain pseudopregnancy, produced a positive decidual reaction. All other reports are negative. The reasons for failure are not clear. Lack of oestrogen-binding capacity has been documented (McGuire & Lisk, 1969) and may play an important rôle; the availability of progesterone receptors in the uteri of such females is unknown.
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