MAINTENANCE OF SPERMATOGENESIS WITH TESTOSTERONE OR DIHYDROTESTOSTERONE IN HYPOPHYSECTOMIZED RATS

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Departments of Anatomy and Physiology, University of Southern California, School of Medicine, Los Angeles, California 90033, U.S.A., and Institute of Biophysics, University of Trondheim, Trondheim 7000, Norway

(Received 18th October 1974)

In an earlier study (Ahmad, Haltmeyer & Eik-Nes, 1973), we reported maintenance of spermatogenesis in tubules of hypophysectomized rats adjoining intratesticular implants of silastic capsules containing testosterone or dihydrotestosterone (DHT). It was suggested that the local differences in the testes of the rats receiving the two treatments might be attributed to the relative amounts of hormone escaping from the silastic capsules. It was calculated that only 8·3 μg DHT/day escaped from the capsule over the course of the experiment compared to 12·0 μg testosterone/day.

In order to compare the maintenance of spermatogenesis in DHT- and testosterone-treated rats with that in normal controls, experiments were undertaken in which larger quantities of hormones than those in the previous study were administered

 

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