MATERNAL INFLUENCE ON POSTIMPLANTATION SURVIVAL IN INBRED RATS

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Authors:
DONALD V. CRAMER
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and
THOMAS J. GILL III
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DOI:
https://doi.org/10.1530/jrf.0.0440317
Volume/Issue:
Volume 44: Issue 2
Page Range:
317–321
Article Type:
Research Article
Online Publication Date:
Aug 1975
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Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, U.S.A.

(Received 6th January 1975)

The derivation and maintenance of inbred strains of animals is frequently difficult or impossible due to reductions in litter size and viability of the offspring. Reductions in litter size might be expected from adverse genetic or environmental effects on components of the reproductive cycle including the ovulation rate, the rate of preimplantation mortality of the zygote and the rate of postimplantation mortality of the embryo. In some strains of inbred mice, the reduction in litter size is largely due to postimplantation losses (Lyon, 1959; Krzanowska, 1960; McCarthy, 1965, 1967). When female mice from inbred strains were mated to males of another strain, the incidence of postimplantation mortality was significantly reduced (McCarthy, 1965). It has been suggested (Lyon, 1959; McCarthy, 1965) that this wastage is the result of an increased number of recessive lethal

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Print ISSN:
1470-1626
Online ISSN:
1741-7899