HYPOTHALAMUS-PITUITARY-TESTIS INTERACTION

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Authors:
P. FRANCHIMONT
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,
S. CHARI
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, and
A. DEMOULIN
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DOI:
https://doi.org/10.1530/jrf.0.0440335
Volume/Issue:
Volume 44: Issue 2
Page Range:
335–350
Article Type:
Research Article
Online Publication Date:
Aug 1975
Free access

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Institute of Medicine, Radioimmunoassay Laboratory, University of Liege, Belgium

The recent observation by Schally & co-authors (1971) that the release of both LH and FSH is dependent upon the one `releasing' hormone (LH-RH) has made the study of the hypothalamus—pituitary—testis axis much more complex. Furthermore, the normal maintenance of both spermatogenesis and testosterone secretion depends upon LH and FSH acting synergistically. It may, therefore, be surmised that there is no absolute specificity of gonadal steroids or other substances in the regulation of secretion of gonadotrophins.

Nevertheless, FSH and LH secretion appear to be dissociated in certain pathological conditions. When the Leydig cells are normal but the germinal epithelium has been damaged or destroyed, as after irradiation, certain viral infections, the administration of anti-fertility agents or in idiopathic infertility, the LH levels stay within the normal range whilst those for FSH are elevated (Franchimont, 1966, 1971, 1972; Paulsen et al., 1968;

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Print ISSN:
1470-1626
Online ISSN:
1741-7899