MICRO-ORGANISMS AND THE APPEARANCE OF LEUCOCYTES IN THE VAGINAL WALL OF CYCLIC FEMALE RATS AT METOESTRUS

P. VAN DER SCHOOT

doi:10.1530/jrf.0.0450061

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MICRO-ORGANISMS AND THE APPEARANCE OF LEUCOCYTES IN THE VAGINAL WALL OF CYCLIC FEMALE RATS AT METOESTRUS

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Author:

P. VAN DER SCHOOT

P. VAN DER SCHOOT
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DOI:: https://doi.org/10.1530/jrf.0.0450061

Volume/Issue:: Volume 45: Issue 1

Page Range:: 61–68

Article Type:: Research Article

Online Publication Date:: Oct 1975

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Summary.

The present study was undertaken to examine whether leucocytic infiltration of the vagina of the rat at metoestrus is dependent on its contamination by micro-organisms. Observations were made on vaginal tissue that had been transplanted under the kidney capsule in cyclic rats, taking care to avoid infection during the transplantation procedure. In such grafts, changes occurred that were associated with ovulation and formation of the CL, but leucocytosis was never obtained at metoestrus. Cyclic changes were observed in the cell patterns of the vaginal smears of germ-free rats, and could be correlated exactly with the ovarian cycle. No leucocytes were present at metoestrus. Many micro-organisms were present in the vagina at pro-oestrus and oestrus in normal cyclic females, but not at metoestrus and dioestrus. It is concluded that the occurrence of leucocytosis in the vagina at metoestrus in normal cyclic female rats depends on the presence of micro-organisms.

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