TEMPORARY STERILITY PRODUCED IN MALE MICE BY 5-THIO-d-GLUCOSE

in Reproduction
Authors:
J. R. ZYSK
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A. A. BUSHWAY
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R. L. WHISTLER
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W. W. CARLTON
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Summary.

When 5-thio-d-glucose was fed to male mice at daily dose levels greater than 30 mg/kg sperm development was completely inhibited within 3 weeks and remained so without impairment of libido for the experimental period of 7 weeks. Removal of this substance from the diet resulted in a resumption of sperm development and fertility within 5 to 8 weeks. Normal litters were sired by males which had recovered after this treatment.

 

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