AN EFFECT OF TAMOXIFEN (I.C.I. 46,474) ON THE SURFACE COAT OF THE LATE PREIMPLANTATION MOUSE BLASTOCYST
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Summary.
The oral administration of Tamoxifen on Days 2, 3 and 4 after mating, or on Day 2 only, was found to prevent the oestrogen-dependent surface-coat change of the late preimplantation blastocyst in the mouse. It is suggested that this is an antioestrogenic manifestation and that it is, at least in part, responsible for the drug's known antifertility effect.
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