INDUCTION OF DECIDUOMATA BY INTRAUTERINE COPPER IN THE RABBIT
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Department of Pharmacology, The School of Pharmacy, University of London, Brunswick Square, London WC1N 1AX (Received 24th February 1975)
In the course of a study on the dissolution of copper in the rabbit uterus (Tobert, 1974), it was observed that copper intrauterine devices (Cu-IUDs), inserted into rabbits 1 day after induction of pseudopregnancy, consistently elicited what appeared to be deciduomata in the endometrium adjacent to the device. Four rabbits, each with an IUD bearing 42 mm2 of copper in one horn and an IUD bearing 14 mm2 of copper in the other, were found to have nodular endometrial masses in the vicinity of the IUD in seven of the eight horns when killed 14 days after insertion of the devices. Subsequent histological examination confirmed that in all seven cases the endometrial masses were composed of decidual cells.
In view of the use of copper as an intrauterine contraceptive
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