Fertilizing ability in vivo and in vitro of spermatozoa of rats and mice treated with μ-chlorohydrin

in Reproduction


The fertilizing ability of epididymal spermatozoa from rats and mice treated for 3 or 4 or 9 or 10 days with various doses of μ-chlorohydrin was tested in vitro, and in vivo by intrauterine insemination. The minimum doses (per kg/day) needed to affect fertilization significantly were: rat, in vitro, 8·8 mg for 3 or 4 days, 4·4 mg for 4 days and 2·7 mg for 9 or 10 days; in vivo, 4·4 mg for 3 or 4 days and 2·7 mg for 9 or 10 days: mouse, in vitro, 4·4 mg for 3 days and 13·3 mg for 9 days; in vivo, 44·2 mg for 3 days and 26·5 for 9 days. Rats were infertile for at least 18 days after receiving 44·2 mg μ-chlorohydrin/kg/day for 3 days, but fertilizing ability, tested in vivo and in vitro, was restored 10-11 days and 15-18 days, respectively, after daily treatment with 11·1 mg μ-chlorohydrin/kg for 3 days.

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