Inhibition of human sperm acrosin by synthetic agents

in Reproduction
Authors:
A. K. Bhattacharyya
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,
L. J. D. Zaneveld
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,
B. M. Dragoje
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,
G. F. B. Schumacher
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, and
J. Travis
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DOI:
https://doi.org/10.1530/jrf.0.0470097
Volume/Issue:
Volume 47: Issue 1
Page Range:
97–100
Article Type:
Research Article
Online Publication Date:
May 1976
Free access

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Summary.

Twenty-two synthetic proteinase inhibitors were tested for their inhibitory properties towards human acrosin. p-Nitrophenyl-p1-guanidino benzoate (NPGB) was the most effective (K1 value of 1·5 × 10−8 M), producing a non-competitive type of inhibition in contrast to all other inhibitors which showed a competitive type of inhibition. The Michaelis constant for human acrosin on BAEE at pH 8·1 was calculated to be 4·25 × 10−5 M.

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Print ISSN:
1470-1626
Online ISSN:
1741-7899