Intraovarian release of eggs in the rat after indomethacin treatment at pro-oestrus

in Reproduction
Authors:
P. Osman
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J. Dullaart
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DOI:
https://doi.org/10.1530/jrf.0.0470101
Volume/Issue:
Volume 47: Issue 1
Page Range:
101–103
Article Type:
Research Article
Online Publication Date:
May 1976
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Department of Anatomy, Medical Faculty, Erasmus University, Rotterdam, The Netherlands

Indomethacin has been shown to block ovulation in rats (Armstrong & Grinwich, 1972; Tsafriri, Lindner, Zor & Lamprecht, 1972a; Orczyk & Behrman, 1972) and other mammals (O'Grady, Caldwell, Auletta & Speroff, 1972; Grinwich, Kennedy & Armstrong, 1972; Saksena, Lau & Shaikh, 1974). The release of LH is not affected in indomethacin-treated rats (Tsafriri et al., 1972b), and it has been suggested that indomethacin exerts its ovulation-inhibiting action at the ovary (Grinwich et al., 1972; Tsafriri et al., 1972a; Saksena et al., 1974). It is not clear, however, how indomethacin affects the mechanism of ovulation, and in the present study the ovaries of rats treated with indomethacin at pro-oestrus were examined histologically.

Adult female rats of the Wistar substrain R'Amsterdam and weighing 180-200 g were used after two consecutive 5-day cycles. Indomethacin (Indocid capsules: Merck, Sharp & Dohme) was suspended in

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Print ISSN:
1470-1626
Online ISSN:
1741-7899