Prostaglandin concentrations in the semen of hypogonadal men during treatment with testosterone
in ReproductionSearch for other papers by N. E. Skakkebaek in
Current site
Google Scholar
PubMed
Search for other papers by R. W. Kelly in
Current site
Google Scholar
PubMed
Search for other papers by C. S. Corker in
Current site
Google Scholar
PubMed
M.R.C. Unit of Reproductive Biology, 2 Forrest Road, Edinburgh EH1 2QW, U.K. and *The Fertility Clinic, University Department of Obstetrics and Gynaecology, Rigshospitalet, Copenhagen, Denmark
Although it has been known for more than 40 years that human semen contains prostaglandins, only recently have 19-hydroxyprostaglandin E-1 and E-2 (19-OH PGEs) been identified as the major prostaglandins in the semen of normal, fertile men (Taylor & Kelly, 1974; Jonsson, Middleditch & Desiderio, 1975). Nothing is known about the control of synthesis and release of these compounds, although there is evidence that the smooth muscle-stimulating activity of human semen, which is attributed to prostaglandins, is androgen dependent (Sturde, 1968). To investigate the role of androgens in the production of 19-OH PGEs, we have measured prostaglandin concentrations in repeated semen samples from two hypogonadal men before and during treatment with testosterone.
Patient 1 was unmarried, aged 26 years; he suffered from a lack of
Reproduction is committed to supporting researchers in demonstrating the impact of their articles published in the journal.
The two types of article metrics we measure are (i) more traditional full-text views and pdf downloads, and (ii) Altmetric data, which shows the wider impact of articles in a range of non-traditional sources, such as social media.
More information is on the Reasons to publish page.
| Sept 2018 onwards | Past Year | Past 30 Days | |
|---|---|---|---|
| Full Text Views | 277 | 167 | 10 |
| PDF Downloads | 104 | 30 | 0 |
Online ISSN: 1741-7899
Print ISSN: 1470-1626
Strengthening biomedical communities
to advance science and health
CONTACT US
Bioscientifica Ltd | Starling House | 1600 Bristol Parkway North | Bristol BS34 8YU | UK
Bioscientifica Ltd | Registered in England no 3190519