I Department of Obstetrics and Gynecology and * Department of Anatomy, University of Helsinki, Helsinki, Finland
It is commonly believed that vasectomy does not cause major changes in testicular morphology in the rat (Smith, 1962; Segal, 1972; Plaut, 1973; Neaves, 1974). Some long-term studies, however, have shown that vasectomy has led to the decline of testicular weight and endocrine function (Sackler, Weltman, Pandhi & Schwartz, 1973; Kinson & Layberry, 1975). Because the germinal epithelium and sperm production in most animals seem to be intact, the epididymis must adapt to accommodate an increasing number of spermatozoa. Dilatation of the cauda epididymidis and the formation of sperm cysts and sperm granulomata have been reported (Smith, 1962; McGlynn & Erpino, 1974), but little is known about the effects of vasectomy on epididymal physiology. Jones (1974) suggested that vasectomy does not seriously impair the functional capacity of the cauda epididymidis. The present study was therefore
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