Effect of ethane 1,2-dimethane sulphonate on the cyclic AMP response in rat testis to stimulation by HCG
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Unit of Reproductive Pharmacology, Department of Pharmacology, University of Manchester, Manchester M13 9PT, U.K.
Ethane 1,2-dimethane sulphonate (EDS: MeSO2.OC2H4O.SO2Me) is a non-steroidal antifertility agent (Cooper & Jackson, 1970). In the rat a single i.p. dose of 75 mg/kg inhibits the production of testosterone by the testis (Bu'Lock & Jackson, 1971/72), the effect being maximal by 7 days after injection and completely overcome in 6-9 weeks (Bu'Lock & Jackson, 1975). While testicular steroidogenesis is depressed, serum and pituitary levels of LH are raised (Morris & Jackson, 1975), suggesting that failure of the testis to produce testosterone is accompanied by, if not actually due to, inability to respond to LH in the normal manner by increasing testosterone formation.
Small quantities of LH or HCG (< 1 ng) stimulate the production and release of cyclic adenosine 3′,5′-monophosphate (cAMP) and of testosterone by the testis in
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