Effects of prostaglandin F-2α and E-2 on the production of progesterone by mouse ovaries in vitro

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Authors:
P. Neal
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,
T. G. Baker
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, and
K. P. McNatty
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DOI:
https://doi.org/10.1530/jrf.0.0470157
Volume/Issue:
Volume 47: Issue 1
Page Range:
157–159
Article Type:
Research Article
Online Publication Date:
May 1976
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Hormone Laboratory, Department of Obstetrics and Gynaecology, University of Edinburgh, and * M.R.C. Unit of Reproductive Biology, 39 Chalmers Street, Edinburgh, EH3 9ER, U.K.

Numerous studies have shown that prostaglandin (PG) E-2 can stimulate ovarian steroidogenesis in vitro and can mimic many of the actions of LH on the Graafian follicle in vivo and in vitro (see Neal, Baker, McNatty & Scaramuzzi, 1975). Paradoxically, however, PGF-2α can stimulate or inhibit steroidogenesis by ovarian follicles or isolated cells in vitro, the response varying with the dose employed.

Many of these diverse actions of PGs may be the result of using pharmacological rather than physiological doses of the drugs (see McNatty, Henderson & Sawers, 1975; Neal et al., 1975). In the present investigation, therefore, the effects of various doses of PGE-2 and PGF-2α, alone and in combination, on the secretion of progesterone by mouse ovaries in vitro, with or without added gonadotrophins, were

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Print ISSN:
1470-1626
Online ISSN:
1741-7899