Autoradiographic study of the effect of actinomycin D on decidual differentiation of stromal cells in the mouse uterus

in Reproduction

The administration of actinomycin D to pregnant mice before the zygote has started to implant does not prevent the early stages of the implantation reaction but does delay, for a period of about 30 h, differentiation of the endometrial stromal cells into decidual cells (Finn & Martin, 1972; Finn & Bredl, 1973). During the period of delay vascular permeability is increased and oedema fluid collects in the stroma. An inhibitory effect of actinomycin D on decidualization has also been demonstrated in the rat (Burin & Sartor, 1965; Sananès & Psychoyos, 1970).

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